何山

博士
Email：heshan@aynu.edu.cn




      主要从事荧光分子探针的设计合成与生物医学传感研究，发展了基于萘酰亚胺的近红外双光子荧光探针的高效构建策略。研究围绕生物体内关键活性物质的原位成像展开，为相关生理过程的实时监测和重大疾病的精准诊断提供高性能分子传感工具。近年来，以第一作者发表SCI论文5篇，获国家发明专利1项。
2019-2026 武汉大学 化学与分子科学学院 分析化学专业 理学博士
2015-2019 郑州大学 化学学院 化学专业 理学学士
暂无
分析化学，荧光探针，生物成像
暂无
1.Shan He, Dao-Huan Zhang, Cong Liu, Xiao-Feng Guo*, Hong Wang*. “Interfacial activation” high-fidelity sensing strategy: Two-photon fluorescence imaging of transmembrane H2S release. Anal. Chem., 2026, 98, 7, 5456–5465.
2.Shan He, Cong Liu, Xiao-Feng Guo, Hong Wang*. A ratiometric NIR two-photon probe for biothiols detection in cellular autophagy and liver injury models. Talanta, 2026, 298, 128975.
3.Shan He1, Cong Liu, Xiao-Feng Guo1, Hong Wang*. Rationally designed NIR-in/out fluorophore scaffold for a high-fidelity probe enabling deep-tissue H2S imaging. Anal. Chim. Acta, 2025, 1378, 344709.
4.Shan He1, Cong Liu, Wei Wang, Xiao-Feng Guo1, Hong Wang*. A novel lysosome-targeted NIR emitting two-photon fluorescent probe and its application in H2S detection. Microchem. J., 2025, 210, 113027.
5.Shan He, Wen-Le Fang, Xiao-Feng Guo, Hong Wang*. A water-soluble two-photon fluorescent probe for rapid and reversible monitoring of redox state. Talanta, 2023, 253, 124066.
6.王红, 何山, 郭小峰. 一种细胞膜靶向型H2S双光子荧光探针及其制备方法与应用, ZL202410695442.6, 2026-05-26.
暂无