张振兴

张振兴，博士，讲师;  E-mail: yoursoul @ 126.com

教育经历：

2009.09-2012.07   博士 南开大学  药学院 化学生物学 (导师：王鹏)

2007.09-2009.06   硕士 南开大学  药学院 药物化学 (导师：王鹏)

2003.09-2007.06   本科 安阳师范学院  化学化工学院 化学 (导师：秦丙昌) 

工作经历：

2017.06-2019.05   博士后 中国北京大学 工学院

2012.12-2016.07   博士后 中国北京大学 化学生物学与生物技术 

研究方向：糖药物化学 光电有机合成 

科研成果: 

(1) 项目

1. NSFC 20902050，促进Th1型免疫应答的糖脂类抗原的合成与活性研究，主要参与者。

2. NSFC 21372013，基于三氮烯导向惰性键官能团化的研究及其在杂环合成与药物分子末期修饰中的应用，主要参与者。

(2) 论文

[1] Zhenxing Zhang, Lei Zhang, Yang Cao, Feng Li, Guangcan Bai, Guoquan Liu, Yang Yang and Fanyang Mo. Mn-Mediated Electrochemical Trifluoromethylation/C(sp2)–H Functionalization Cascade for the Synthesis of Azaheterocycles
Org. Lett. 2019, 20, 762-766. IF：6.94中科院JCR分区大类 1区

[2] Lei Zhang, Zhenxing Zhang(共同一作), Jianning Zhang, Kangle Li and Fanyang Mo. Oxidant-free oxidation of C−H bond by cathodic hydrogen evolution: a phosphonic Kolbe oxidation/cyclization process
Green Chem. 2018, 20, 3916-3920. IF：8.59中科院JCR分区大类 1区

[3] Lei Zhang, Zhenxing Zhang(共同一作), Junting Hong, Jian Yu, Jianning Zhang, Fanyang Mo. Oxidant-Free C(sp2)−H Functionalization/C−O Bond Formation: A Kolbe Oxidative Cyclization Process
J. Org. Chem. 2018, 83, 3200–3207. IF：4.80中科院JCR分区大类 2区

[4] Zhenxing Zhang, Hao Jiang, Yong Huang. Ruthenium catalyzed redox neutral C-H activation via N-N cleavage: synthesis of N-substituted indoles.
Org. Lett.. 2014,16, 5976−5979  IF：6.94中科院JCR分区大类 1区

[5] Zhenxing Zhang, Wei Zhao, Bin Wang, Chengfeng Xia, Wenpeng Zhang, Peng George Wang.  The Total Synthesis of Immunostimulant α-Galactosylceramides from Naturally Configured α-Galactoside Raffinose
Org. Lett. 2011, 13, 4530-4533. IF：6.94中科院JCR分区大类 1区   

[6] Zhen-Xing Zhang , Baolin Wuc, Bin Wang, Tie-Hai Li , Peng-Fei Zhang , Li-Na Guo , Wen-jun Wang,Wei Zhao a, Peng George Wang. Facile and stereo-controlled synthesis of 2-deoxynojirimycin, Miglustat and Miglitol
Tetrahedron Letters 52 (2011) 3802–3804 IF：2.12中科院JCR分区大类 3区

[7] Wang Jia-jia, Zhang Zhen-xing, Li Tie-hai, Guo Li-na, Liu Yan-kun, Zhao Wei. An improved strategy to synthesize N-butyl-1-deoxynojirimycin
Chinese Jounrnal of Medicinal Chemistry 21 (2011) 298-303 

[8] Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang , Lei Li, Jianping Lin,Wei Zhao, Jing Li, Peng George Wang. Design and synthesis of O-GlcNAcase inhibitors via Click Chemistry and biological evaluations.
Carbohydrate Research.. 346,（2011）1083-1092   IF  1.9

[9] Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao Peng George Wang .. Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors.
Bioorganic & Medicinal Chemistry. 19 (2011) 2136–2144   IF 3.0

[10] TIAN Ye， YANG Pin, YIN Zhi-Dong, ZHOU Li-Fei, ZHANG Zhen-Xing, WANG Shuai , WANG Peng, WANG Bin* Advances in anti-influenza drugs: neuraminidase inhibitors.
Chinese Jounrnal of Medicinal Chemistry  20 (2010) 531-542

Wang, B.; Wang, S. A.; Zhang, Z. X.; Yang, P.; Tian, Y.; Wang, P.; Zhang, Q.; Bai, G. Chinese Journal of Structural Chemistry 2009, 28, 1008.

(3) 专利

1. 申请号：201911053250.0， 电化学氧化合成4-磺酸取代异喹啉酮衍生物的方法，张振兴，董茹，李刚，秦丙昌。

2. 申请号：CN201910308719.4，一种电化学氧化方法控制的制备酮或β-羰基酯的方法，孙北奇，张振兴，赵玉，张雷，莫凡洋

(4) 获奖
2012届南开大学优秀毕业生